![]() In contrast to the brain tropism of Bp, Bbss spirochetes were found in ear, skin, joint, bladder, and heart tissue samples of only ID-inoculated mice. Regardless of ID or IV injection, DNA of Bp was present in blood samples up to day 24 post-challenge, while no Bbss was detectable in the blood circulation during the complete observation period. Specific antibodies in individual plasma/serum samples were detected with serological methods. By in vitro culture and PCR, viable spirochetes and their DNA load in peripheral blood were periodically monitored during a 49/50-day course post-injection, as well as in various tissue samples collected at day 49/50. persica ( Bp) after either intradermal (ID) injection into the dorsal skin of immunocompetent mice or strict intravenous (IV) inoculation via the jugular vein. burgdorferi sensu stricto ( Bbss) were compared to those of B. ![]() Survival capacity and infectivity of host-adapted B. In this study, we established a strict intravenous infection murine model using host-adapted spirochetes. Currently the exact dissemination pathway of LB pathogens in the host is not known and controversially discussed. Borrelia persica causes relapsing fever and is able to replicate in the blood stream. It is generally believed that this spirochete disseminates via the hematogenous route. ![]() After an initial tick bite, it spreads from the deposition site in the dermis to distant tissues of the host. Borrelia burgdorferi is a tick-borne spirochete that causes Lyme borreliosis (LB).
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